6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; 6PF-2-K/fru-2,6-P2ase 1; PFK/FBPase 1; 6PF-2-K/fru-2,6-P2ase liver isozyme; includes: 6-phosphofructo-2-kinase; fructose-2,6-bisphosphatase (PFKFB1, F6PK PFRX)

Function

• dual function phosphomonoesterase
• synthesis & degradation of fructose-2,6-bisphosphate
• phosphorylation results in inhibition of kinase activity

ATP + D-fructose-6-phosphate -> ADP + D-fructose-2,6-bisphosphate

D-fructose-2,6-bisphosphate + H2O -> D-fructose-6-phosphate + phosphate

Structure

• homodimer
• in the C-terminal section; belongs to the phosphoglycerate mutase family

Expression

liver

More general terms

• 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase
• allosteric enzyme
• oligomerizing protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5207
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5207
• OMIM: https://mirror.omim.org/entry/311790
• UniProt: http://www.uniprot.org/uniprot/P16118.html