isoprostane
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Introduction
Isoprostanes are formed in situ by peroxidation
Structure
- 3 major structural isomers of F2 isoprostanes are formed from a common endoperoxide intermediate: F2-isoprostanes* by reduction & D2/E2-isoprostanes* by isomerization.
* It would appear that these are the prostaglandins
Laboratory
- isoprostanes as markers of lipid peroxidation in Alzheimer's disease is under development as a diagnostic urine test[3][4]
More general terms
References
- ↑ Montine KS, Quinn JF, Zhang J, Fessel JP, Roberts LJ 2nd, Morrow JD, Montine TJ. Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chem Phys Lipids. 2004 Mar;128(1-2):117-24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15037157
- ↑ Musiek ES, Cha JK, Yin H, Zackert WE, Terry ES, Porter NA, Montine TJ, Morrow JD. Quantification of F-ring isoprostane-like compounds (F4-neuroprostanes) derived from docosahexaenoic acid in vivo in humans by a stable isotope dilution mass spectrometric assay. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jan 5;799(1):95-102. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14659440
- ↑ 3.0 3.1 Pratico D, Clark CM, Liun F, Rokach J, Lee VY, Trojanowski JQ. Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch Neurol. 2002 Jun;59(6):972-6. Erratum in: Arch Neurol 2002 Sep;59(9):1475. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12056933
- ↑ 4.0 4.1 Urine Testing for Alzheimer's Disease Lab Tests Online http://www.labtestsonline.org/news/alzheimer020717.html