PAS domain-containing protein 1 (OX-TES-1, cancer/testis antigen 63, CT63, PASD1)

Function

• may function as a transcription factor

Structure

contains 1 PAS (PER-ARNT-SIM) domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2 Note=Due to intron retention

Expression

• testis-specific

Pathology

• found in histologically normal tissues from patients with uterine cancer , lung cancer & small intestine cancer
• widespread expression seen in solid tumors & diffuse large B-cell lymphoma (DLBCL)-derived cell lines
• isoform 2 is expressed in all DLBCL-derived cell lines
• isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL

More general terms

• transcription factor (TF)
• testis-specific protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IV76.html