MKL/myocardin-like protein 2 (myocardin-related transcription factor B, MRTF-B, megakaryoblastic leukemia 2, MKL2, KIAA1243, MRTFB)

Function

• transcriptional coactivator of serum response factor (SRF)
• required for skeletal myogenic differentiation
• interacts with MKL1 & SRF

Structure

• contains 3 RPEL repeats
• contains 1 SAP domain
• N-terminal region is required for nuclear localization
• C-terminal region mediates transcriptional activity

Compartment

nucleus

Alternative splicing

named isoforms=4

More general terms

• transcription factor (TF)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9ULH7.html