zinc finger homeobox protein 4 (zinc finger homeodomain protein 4, ZFH-4, ZFHX4)

Function

• role in neural & muscle differentiation
• role in transcriptional regulation

Structure

• belongs to the krueppel C2H2-type zinc-finger protein family.
• contains 20 C2H2-type zinc fingers
• contains 4 homeobox DNA-binding domains

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• expressed in brain, skeletal muscle & liver
• very low expression in stomach.

Pathology

• chromosomal Translocation t(1;8)(p34.3;q21.12) involving ZFHX4 is found in one patient with ptosis

More general terms

• C2H2 type zinc finger protein
• homeobox protein
• transcription factor (TF)

Database

• UniProt: http://www.uniprot.org/uniprot/Q86UP3.html