zinc finger protein IA1; insulinoma-associated protein 1 (INSM1, IA1)

Function

• may be associated with the transformation of neuroendocrine cells

Structure

contains 5 C2H2-type Zn+2 fingers

Compartment

nucleus (putative)

Expression

• not found in any of the normal tissues tested

Pathology

• expressed in several tumor cell lines of neuroendocrine origin including
  • pheochromocytoma
  • medullary thyroid carcinoma
  • insulinoma
  • pituitary tumor
  • small cell lung carcinoma

More general terms

• DNA-binding protein
• C2H2 type zinc finger protein
• transcription factor (TF)

Database

• UniProt: http://www.uniprot.org/uniprot/Q01101.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3642
• OMIM: https://mirror.omim.org/entry/600010