eukaryotic translation initiation factor 4E transporter; 4E-T; eIF4E transporter; eukaryotic translation initiation factor 4E nuclear import factor 1 (EIF4ENIF1)

Function

• nucleoplasmic shuttling protein
• mediates the nuclear import of EIF4E by a piggy-back mechanism
• interacts with EIF4E
• interacts with importin beta only in the presence of importin alpha

Compartment

• cytoplasm, nucleus
• predominantly cytoplasmic
• shuttles between the nucleus & the cytoplasm (CRM1-dependent)

Alternative splicing

named isoforms=2

Expression

widely expressed

More general terms

• carrier protein (transporter)
• phosphoprotein

Additional terms

• eukaryotic translation initiation factor 4E (eIF4E, mRNA cap-binding protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56478
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56478
• OMIM: https://mirror.omim.org/entry/607445
• UniProt: http://www.uniprot.org/uniprot/Q9NRA8.html