K+ channel subfamily N member 4; intermediate conductance Ca+2-activated K+ channel protein 4; SK4; SKCa 4; SKCa4; IKCa1; IK1; KCa3.1; KCa4; Gardos channel (KCNN4, IK1, IKCA1, KCA4, SK4)

Function

• voltage-independent K+ channel activated by intracellular Ca+2
• intermediate conductance
• activation is followed by membrane hyperpolarization & Ca+2 influx
• blocked by clotrimazole & charybdotoxin
  • insensitive to apamin
• heterotetramer of K+ channel proteins (probable)
• interacts with MTMR6

Structure

• belongs to the K+ channel KCNN family KCa3.1/KCNN4 subfamily

Compartment

membrane

Expression

• widely expressed in nonexcitable tissues
• up-regulated by phorbol myristate acetate & phytohemagglutinin in T-cells

Pharmacology

• inhibited by senicapoc, an investigation agent used in treatment of sickle cell disease

More general terms

• transmembrane 6 protein
• calmodulin binding protein
• K+ channel subfamily N

Component of

• Ca+2-activated K+ channel

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3783
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3783
• OMIM: https://mirror.omim.org/entry/602754
• UniProt: http://www.uniprot.org/uniprot/O15554.html