mediator of RNA polymerase II transcription subunit 26; activator-recruited cofactor 70 kD component; ARC70; cofactor required for Sp1 transcriptional activation subunit 7; CRSP complex subunit 7; mediator complex subunit 26; transcriptional coactivator CRSP70 (MED26, ARC70, CRSP7)

Function

• component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes

Structure

• belongs to the mediator complex subunit 26 family
• contains 1 TFIIS N-terminal domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

More general terms

• transcription factor (TF)
• phosphoprotein

Component of

• activator-recruited cofactor (ARC)/DRIP
• mediator complex (mediator of RNA polymerase 2 transcription)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9441
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9441
• OMIM: https://mirror.omim.org/entry/605043
• UniProt: http://www.uniprot.org/uniprot/O95402.html