transient receptor potential cation channel subfamily M member 2 (TrpM2, long transient receptor potential channel 2, LTrpC2, LTrpC-2, transient receptor potential channel 7, TrpC7, estrogen-responsive element-associated gene 1 protein, EREG1, KNP3)
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Function
- nonselective, voltage-independent cation channel
- mediates Na+ & Ca+2 influx in response to oxidative stress
- intracellular Ca+2 activates channel
- activated by ADP-ribose, NAD+, reactive nitrogen species & arachidonic acid
- ADP-ribose pyrophosphatase activity
- inactivated by intracellular ATP
- confers susceptibility to cell death following oxidative stress
ADP-ribose + H2O <--> AMP + D-ribose-5-phosphate
- KM=100 uM for ADP-ribose
- Vmax=0.1 umol/min/mg enzyme
Compartment
membrane
Alternative splicing
named isoforms=3
- isoform 2 not regulated by ADP-ribose .
- isoform 1 can interact with isoform 3
- interaction decreases Ca+2 influx through isoform 1 & suppresses susceptibility to oxidative stress-induced cell death
Expression
- expressed in brain, neutrophils > bone marrow, spleen, heart, liver, lung
- isoform 2 is found in neutrophils
More general terms
- transient receptor potential cation channel subfamily M (TRPM)
- Ca+2 channel
- Na+ channel
- transmembrane 6 protein