ADP-ribose pyrophosphatase, mitochondrial; ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; adenosine diphosphoribose pyrophosphatase; ADPR-PPase; nucleoside diphosphate-linked moiety X motif 9; Nudix motif 9 (NUDT9, PSEC0099, UNQ3012/PRO9771)

Function

• hydrolyzes ADP-ribose (ADPR) to AMP & ribose 5'-phosphate
• interacts with C17orf25

ADP-ribose + H2O = AMP + D-ribose-5-phosphate

Cofactor: Mg+2, Mn+2

Inhibition:

• isoform 1 is inhibited by fluoride & N-acetyl-p-benzoquinoneimine

Structure

• monomer
• belongs to the Nudix hydrolase family, NudF subfamily
• contains 1 nudix hydrolase domain

Compartment

isoform 1: mitochondrion

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed
• isoform 1 is the most predominant isoform

More general terms

• pyrophosphatase (diphosphohydrolase)
• phosphoprotein

Additional terms

• ADP ribose

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=53343
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:53343
• OMIM: https://mirror.omim.org/entry/606022
• UniProt: http://www.uniprot.org/uniprot/Q9BW91.html