CD93; complement component C1q receptor; complement component 1 q subcomponent receptor 1; C1q/MBL/SPA receptor; C1qR(p); C1qRp; C1qR; matrix-remodeling-associated protein 4; CDw93; collectin receptor (CC1QR1, MXRA4)

Function

• receptor for & enhances phagocytosis of:
  • C1q
  • mannose-binding lectin (MBL) &
  • pulmonary surfactant protein A (SPA)
• may mediate the enhancement of phagocytosis in monocytes & macrophages upon interaction with soluble defense collagens
• may play a role in intercellular adhesion
• interacts with HCV core protein

Structure

• N- & O-glycosylated
• contains 1 C-type lectin domain
• contains 5 EGF-like domains

Compartment

membrane

Expression

• granulocytes
• monocytes
• platelets
• endothelial cells
• not expressed in lymphoid cells

Pathology

• expressed in:
  • AML myeloblasts

More general terms

• CD antigen
• complement receptor
• C-type lectin superfamily

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22918
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23447
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2291
• OMIM: https://mirror.omim.org/entry/120577
• UniProt: http://www.uniprot.org/uniprot/Q9NPY3.html