WAP, kazal, immunoglobulin, kunitz & NTR domain-containing protein 2 (WAP, follistatin, immunoglobulin, kunitz & NTR domain-containing-related protein, WFIKKN-related protein, growth & differentiation factor-associated serum protein 1, GASP-1, hGASP-1, WFIKKN2, GASP1, WFIKKNRP, UNQ9235/PRO31996)

Function

• protease-inhibitor
• multiple distinct protease inhibitor domains
• probably has serine protease- & metalloprotease-inhibitor activity
• inhibits the biological activity of mature myostatin, but not activin (putative)
• interacts with both mature & propeptide myostatin/MSTN

Structure

• belongs to the WFIKKN family
• contains 2 BPTI/Kunitz inhibitor domains
• contains 1 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 Kazal-like domain
• contains 1 NTR domain
• contains 1 WAP domain

Compartment

secreted (putative)

Expression

• primarily expressed in ovary, testis & brain, but not in liver.
• in fetal tissues, primarily expressed in brain, skeletal muscle, thymus & kidney

More general terms

• secreted protein
• glycoprotein
• serine protease inhibitor; serpin

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TEU8.html