alpha-1-antitrypsin-related protein; Serpin A2 (SERPINA2, SERPINA2P, ARGS, ATR, PIL)

Function

• could be a serine protease inhibitor

Structure

• the reactive center loop (RCL) extends out from the body of the protein & directs binding to the target protease
• the protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site & the Ser hydroxyl of the protease
• the resulting inactive serpin-protease complex is highly stable
• belongs to the serpin family

Notes

could be the product of a pseudogene

More general terms

• alpha 1 globulin
• serine protease inhibitor; serpin
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/107410
• UniProt: http://www.uniprot.org/uniprot/P20848.html