alpha-2-antiplasmin; alpha-2-AP; alpha-2-plasmin inhibitor; alpha-2-PI; Serpin F2 (SERPINF2, AAP, PLI)

Function

• inhibits plasmin by forming an irreversible complex with catalytic site
• prevents plasmin binding to fibrin & is itself bound to fibrin by Factor XIIIa
• major targets of this inhibitor are plasmin & trypsin, but it also inactivates chymotrypsin

Structure

• belongs to the serpin family

Compartment

secreted

Expression

• expressed by the liver & secreted in plasma

Pathology

• defects in SERPINF2 are the cause of alpha-2-antiplasmin deficiency

More general terms

• alpha 2 globulin
• serine protease inhibitor; serpin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5345
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5345
• OMIM: https://mirror.omim.org/entry/262850
• OMIM: https://mirror.omim.org/entry/613168
• UniProt: http://www.uniprot.org/uniprot/P08697.html