phosphatidylethanolamine-binding protein 1 (PEBP-1, prostatic-binding protein, HCNPpp, neuropolypeptide h3, Raf kinase inhibitor protein, RKIP, [Contains: Hippocampal cholinergic neurostimulating peptide (HCNP)], PEBP1, PBP, PEBP)

Function

• binds ATP, opioids & phosphatidylethanolamine
• lower affinity for phosphatidylinositol & phosphatidylcholine
• serine protease inhibitor
• inhibits thrombin, neuropsin & chymotrypsin but not trypsin, tissue type plasminogen activator & elastase
• precursor of hippocampal cholinergic neurostimulating peptide
• interacts with Raf-1 & seems to inhibit it
• HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system
• HCNP increases production of choline acetyltransferase but not acetylcholinesterase
• seems to be mediated by a specific receptor

Structure

• belongs to phosphatidylethanolamine-binding protein family

Compartment

cytoplasm

More general terms

• phosphatidylethanolamine [PE]-binding protein
• serine protease inhibitor; serpin
• protein precursor

Database

• UniProt: http://www.uniprot.org/uniprot/P30086.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5037
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5037
• OMIM: https://mirror.omim.org/entry/604591