protein phosphatase 1 regulatory subunit 14A; 17 kD PKC-potentiated inhibitory protein of PP1; protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17 (PPP1R14A, CPI17, PPP1INL)

Function

• inhibitor of PPP1CA
• > 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates & smooth muscle contraction

Structure

belongs to the PP1 inhibitor family

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=2

Expression

• isoform 1 is detected in aorta & testis
• isoform 2 is detected in aorta

More general terms

• protein phosphatase-1 regulatory subunit

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=94274
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:94274
• OMIM: https://mirror.omim.org/entry/608153
• UniProt: http://www.uniprot.org/uniprot/Q96A00.html