protein phosphatase 1 regulatory subunit 1A; protein phosphatase inhibitor 1; I-1; IPP-1 (PPP1R1A, IPP1)

Function

• inhibitor of protein-phosphatase 1
• may have role in hormonal control of glycogen metabolism
• hormones that elevate intracellular cAMP increase PPP1R1A activity in many tissues
• PPP1R1A activation may impose cAMP control over proteins that are not directly phosphorylated by PKA
• following a rise in intracellular Ca+2, PPP1R1A is inactivated by calcineurin (or PP2B)
• does not inhibit type-2 phosphatases
• phosphorylation of Thr-35 is required for activity
• interacts with PPP1R15A

Structure

• belongs to the protein phosphatase inhibitor 1 family

More general terms

• protein phosphatase-1 regulatory subunit

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5502
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5502
• OMIM: https://mirror.omim.org/entry/613246
• UniProt: http://www.uniprot.org/uniprot/Q13522.html