CDw119; interferon-gamma receptor alpha chain; IFN-gamma-R1; CD119 (IFNGR1)
Jump to navigation
Jump to search
Function
- receptor for interferon gamma
- 2 receptors bind 1 interferon-gamma dimer
- phosphorylated at Ser/Thr
Structure
- monomer
- belongs to the type 2 cytokine receptor family
- contains 2 fibronectin F3 modules
- contains 2 Ig-like C2-type domains (immunoglobulin-like)
Compartment
- membrane
Pathology
- defects in IFNGR1 are a cause of Mendelian susceptibility to mycobacterial disease[8]
Polymorphism
- genetic variation in the IFNGR1 gene is associated with susceptibility to Helicobacter pylori infection [MIM:600263]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P15260.html
- ↑ IFNGR1base; Note: IFNGR1 mutation db http://bioinf.uta.fi/IFNGR1base/
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=IFNGR1
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/ifngr1/
- ↑ Taga T & Kishimoto T Cytokine receptors and signal transduction FASEB J 6:3387 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1334470
- ↑ Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/8048164
- ↑ <Internet> http://www.pathologyoutlines.com/cd100247.html 21 June 2005
- ↑ 8.0 8.1 Holland SM, Pierce VM, Shailam R, Glomski K, Farmer JR. Case 28-2017. A 13-Month-Old Girl with Pneumonia and a 33-Year-Old Woman with Hip Pain. N Engl J Med. 2017 Sep 14;377(11):1077-1091. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28902581 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMcpc1706097