ecto-ADP-ribosyltransferase 4; Dombrock blood group carrier molecule; mono(ADP-ribosyl)transferase 4; NADP+-arginine ADP-ribosyltransferase 4; CD297 (ART4, DO, DOK1)

Function

• arginine-specific ADP ribosyltransferase

Structure

• belongs to the Arg-specific ADP-ribosyltransferase family

Compartment

• cell membrane; lipid-anchor, GPI-anchor

Expression

• expressed in spleen & T-cells

Polymorphism

• ART4 (DO) is responsible for the Dombrock blood group system
• the molecular basis of the Do(a)/Do(b) blood group antigen is a single variation in position 265
  • Asn-265 corresponds to Do(a)
  • Asp-265 to Do(b)
• also responsible for antigens
  • Gregory [Gy(a)]
  • Holley [Hy]
  • Joseph [Jo(a)]

More general terms

• arginine specific ADP-ribosyltransferase
• CD antigen
• glypiated protein
• blood group antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=420
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:420
• OMIM: https://mirror.omim.org/entry/110600
• UniProt: http://www.uniprot.org/uniprot/Q93070.html