CD151 antigen; platelet-endothelial tetraspan antigen 3; PETA-3; GP27; membrane glycoprotein SFA-1; tetraspanin-24; Tspan-24 (CD151, TSPAN24)
Jump to navigation
Jump to search
Function
- essential for the proper assembly of the glomerular & tubular basement membranes in kidney
- interacts with integrins alpha3beta1, alpha5beta1, & alpha6beta4, with CD9 & CD181
Structure
- belongs to the tetraspanin (TM4SF) family
Compartment
membrane
Expression
- expressed in a variety of tissues including vascular endothelium & epidermis
- expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes
- induced by HTLV-1
Pathology
- defects in CD151 are the cause of nephropathy with pretibial epidermolysis bullosa & deafness
Polymorphism
- CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system.
- 92% of Caucasians are MER2-positive & 8% are apparently MER2-negative
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P48509.html dbRBC/BGMUT; Note: Blood group antigen gene mutation database http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=raph
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/cd151/
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=977
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:977
- OMIM: https://mirror.omim.org/entry/179620
- OMIM: https://mirror.omim.org/entry/602243
- OMIM: https://mirror.omim.org/entry/609057
- UniProt: http://www.uniprot.org/uniprot/P48509.html