CD105 or endoglin

Function

• regulatory component of TGF-beta receptor complex
• mediates cellular response to TGF-beta 1

Expression

• activated monocytes
• endothelial cells
• erythroid precursors in marrow
• syncytiotrophoblasts, cytotrophoblasts in first trimester (transient)

Pathology

• mutations associated with: hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome)

Laboratory

• ENG gene mutation

More general terms

• CD antigen
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P17813.html
• OMIM: https://mirror.omim.org/entry/131195
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2022