GAGE-7 protein; G antigen 7; GAGE-7; AL4; cancer/testis antigen 4.7; CT4.7; GAGE-7B; GAGE-8 (GAGE7, GAGE7B)
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Function
- antigen
- recognized on melanoma by autologous cytolytic T-cells (see Genetics:)
Structure
belongs to the GAGE family
Expression
- exressed specifically in testis
Pathology
- expressed in several tumor tissues including melanoma
Genetics
- gene belongs to a family of genes organized in clustered repeats
- the genes have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution
- their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
More general terms
References
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100008
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2579
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26748
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=645073
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:100008
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2579
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26748
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:645073
- OMIM: https://mirror.omim.org/entry/300601
- OMIM: https://mirror.omim.org/entry/300637
- UniProt: http://www.uniprot.org/uniprot/O76087.html