GAGE-3 protein; G antigen 3; GAGE-3; cancer/testis antigen 4.3; CT4.3 (GAGE3)

Function

• antigen
  • recognized on melanoma by autologous cytolytic T-cells (see Genetics:)

Structure

belongs to the GAGE family

Expression

• exressed specifically in testis

Pathology

• expressed in several tumor tissues including melanoma

Genetics

• gene belongs to a family of genes organized in clustered repeats
  • the genes have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution
  • their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

Notes

• UniProt :accession Q13067 withdrawn 2017

More general terms

• GAGE protein (G antigen family)
• phosphoprotein
• testis-specific protein

Database

• OMIM: https://mirror.omim.org/entry/300596