G antigen 1; GAGE-1; antigen MZ2-F; cancer/testis antigen 4.1; CT4.1 (GAGE1)
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Function
- antigen
- recognized on melanoma by autologous cytolytic T-cells (see Genetics:)
- completely silent in normal adult tissues, except testis
Structure
belongs to the GAGE family
Expression
- exressed specifically in testis
Pathology
- expressed in several tumor tissues including melanoma
Genetics
- gene belongs to a family of genes organized in clustered repeats
- the genes have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution
- their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P0DTW1.html
- ↑ UniProt PubMed refs
PMID: https://www.ncbi.nlm.nih.gov/pubmed/7544395 - ↑ OMIM https://mirror.omim.org/entry/300594