sphingomyelin phosphodiesterase 3; neutral sphingomyelinase 2; sphingomyelinase-3; nSMase2 (SMPD3)

Function

• catalyzes the hydrolysis of sphingomyelin to form ceramide & phosphocholine
• hydrolyzes sphingosylphosphocholine
• regulates the cell cycle by acting as a growth suppressor in confluent cells
• regulation of postnatal development
• involvement in bone & dentin mineralization
• activated by unsaturated fatty acids & phosphatidylserine

Cofactor: Mg+2

Kinetic parameters: Optimum pH is 7.5

Compartment

• integral membrane protein
• Golgi, may localize to detergent-resistant subdomains of Golgi membranes in hypothalamic neurosecretory neurons
• localizes to plasma membrane in confluent contact-inhibited cells

Expression

• predominantly expressed in brain
• up-regulated during G0/G1 phases

More general terms

• sphingomyelinase, sphinogomyelin phosphodiesterase
• transmembrane 2e protein

Additional terms

• sphingomyelin

Database

• OMIM: https://mirror.omim.org/entry/605777
• UniProt: http://www.uniprot.org/uniprot/Q9NY59.html