caspase-14; apoptosis-related cysteine protease (CASP14)

Function

• believed to be a non-apoptotic caspase involved in epidermal differentiation
• role in keratinocyte differentiation & cornification
• probably regulates maturation of the epidermis by proteolytically processing filaggrin

Structure

• complex of unprocessed caspase-14 & processed 19 kDa (p19) & 10 kD (p10) subunits
• belongs to the peptidase C14 family

Compartment

cytoplasm. nucleus

Expression

• expressed in kerotinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum & stratum corneum) (at protein level)
• expressed in keratinocytes of hair shaft & sebaceous glands (at protein level)
• expressed in undifferentiated keratinocytes under postconfluency growth conditions (in vitro)

Pathology

• expressed in psoriatic skin only expressed at very low levels

More general terms

• caspase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2358
• OMIM: https://mirror.omim.org/entry/605848
• UniProt: http://www.uniprot.org/uniprot/P31944.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23581