15 kD selenoprotein (SEP15)

Function

• may be involved in redox reactions associated with formation of disulfide bonds
• may contribute to quality control of protein folding in the endoplasmic reticulum
• forms a tight complex with UGGT1/UGCGL1 (putative)

Structure

• the N-terminus is blocked
• belongs to the selenoprotein M/SEP15 family

Compartment

• endoplasmic reticulum lumen
• association with UGGT1/UGCGL1 is required for its retention in the endoplasmic reticulum

Alternative splicing

named isoforms=2

Expression

• higher expression in prostate & thyroid gland

More general terms

• selenoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9403
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9403
• OMIM: https://mirror.omim.org/entry/606254
• UniProt: http://www.uniprot.org/uniprot/O60613.html