UDP-glucose:glycoprotein glucosyltransferase 1; UGT1; hUGT1; UDP-Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1 (UGGT1, GT, UGCGL1, UGGT, UGT1, UGTR)

Function

• recognizes glycoproteins with minor folding defects
• reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum
• reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum & refolding or degradation
• functions as monomer or heterodimer with SEP15
• N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects

Cofactor: Ca+2 or Mn+2

Structure

• the N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects
• belongs to the glycosyltransferase 8 family

Compartment

• endoplasmic reticulum lumen
• endoplasmic reticulum-Golgi intermediate compartment

Expression

• expressed in pancreas, skeletal muscle, kidney, brain > lung, heart
• induced by tunicamycin, A23187; 3-4 fold induction 10 hrs after treatment

More general terms

• glucosyl transferase
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56886
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56886
• OMIM: https://mirror.omim.org/entry/605897
• UniProt: http://www.uniprot.org/uniprot/Q9NYU2.html