tRNA-dihydrouridine synthase 2-like (hDUS2, up-regulated in lung cancer, URLC8, DUS2L, DUS2)

Function

• dihydrouridine synthase
• catalyzes synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs
• interacts with EPRS

Cofactor: FAD

Structure

• belongs to the dus family, Dus2 subfamily
• contains 1 DRBM domain (double-stranded RNA-binding)

Compartment

• cytoplasm, endoplasmic reticulum
• mainly at the endoplasmic reticulum

Expression

• weak expression in heart, placenta, skeletal muscle

Pathology

• p-regulated in most lung cancer cells (at protein level)

More general terms

• oxidoreductase
• flavoprotein
• RNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NX74.html