bifunctional aminoacyl-tRNA synthetase (prolyl tRNA synthetase, glutamyl tRNA synthetase, EPRS, GLNS, PARS, QARS, QPRS, PIG32)

Function

• component of the multisynthetase complex
• interacts with DUS2L

ATP + L-glutamate + tRNA(Glu)
             <-->
AMP + diphosphate + L-glutamyl-tRNA(Glu)

ATP + L-proline + tRNA(Pro)
            <-->
AMP + diphosphate + L-prolyl-tRNA(Pro)

Structure

• WHEP-TRS domain is involved in RNA binding
• aminoacyl-tRNA synthetase family
• contains 3 WHEP-TRS domains
• N-terminal section, amino acyl tRNA synthetase-1
• C-terminal section, amino acyl tRNA synthetase-2

Notes

originally thought to be a glutaminyl-tRNA synthetase

More general terms

• amino acyl tRNA synthetase
• multifunctional enzyme
• phosphoprotein

Component of

• multisynthetase complex

Database

• OMIM: https://mirror.omim.org/entry/138295
• UniProt: http://www.uniprot.org/uniprot/P07814.html