all-trans-retinol 13,14-reductase; all-trans-13,14-dihydroretinol saturase; RetSat; PPAR-alpha-regulated & starvation-induced gene protein (RETSAT, PPSIG, UNQ439/PRO872)

Function

• retinol saturase, metabolism of vitamin A
• saturation of the 13-14 double bond of all-trans-retinol to produce all-trans-13,14-dihydroretinol
• activity toward all-trans-retinol as substrate
• does NOT use all-trans-retinoic acid nor 9-cis-retinol, 11-cis-retinol or 13-cis-retinol isomers as substrates

Cofactor: NAD, NADP, or FAD

Structure

• belongs to the carotenoid/retinoid oxidoreductase family, CrtISO subfamily

Compartment

endoplasmic reticulum membrane, peripheral membrane

Alternative splicing

named isoforms=2

More general terms

• flavoprotein
• oxidoreductase
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54884
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54884
• UniProt: http://www.uniprot.org/uniprot/Q6NUM9.html