interleukin-4 induced protein 1; L-amino-acid oxidase; LAAO; LAO; IL4-induced protein 1; protein Fig-1; hFIG1 (IL4I1, FIG1, UNQ636/PRO1265)

Function

• lysosomal L-amino-acid oxidase
• highest specific activity with phenylalanine
• may play a role in lysosomal antigen processing & presentation

L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2

Cofactor: FAD (putative)

Structure

• belongs to the flavin monoamine oxidase family, FIG1 subfamily

Compartment

• isoform 1: lysosome (putative)
• isoform 2: lysosome (putative)

Alternative splicing

named isoforms=2

Alternative promoter usage

• uses the promoter of the upstream NUP62 gene & shares the first 2 non-coding exons with NUP62

Expression

• isoform 1 is primarily found in immune tissues
• induced by IL4/interleukin-4

Pathology

• IL4I1 may diminish inflammation & enhance re-myelination in multiple sclerosis

More general terms

• glycoprotein
• flavoprotein

Additional terms

• interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; binetrakin; lymphocyte stimulatory factor 1; pitrakinra (IL4)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=259307
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:259307
• OMIM: https://mirror.omim.org/entry/609742
• UniProt: http://www.uniprot.org/uniprot/Q96RQ9.html