sulfhydryl oxidase 2; neuroblastoma-derived sulfhydryl oxidase; quiescin Q6-like protein 1 (QSOX2, QSCN6L1, SOXN)

Function

• catalyzes the oxidation of sulfhydryl groups in peptide & protein thiols to disulfides with reduction of O2 to H2O2
• disulfide bond formation in a variety of secreted proteins
• regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis

Cofactor: binds 1 FAD per subunit

Structure

• monomer
• belongs to the quiescin-sulfhydryl oxidase (QSOX) family
• contains 1 ERV/ALR sulfhydryl oxidase domain
• contains 1 thioredoxin domain

Compartment

• membrane, secreted
• seems to be predominantly targeted to the nuclear membrane & outer plasma membrane

Expression

• expressed in pancreas, brain, placenta, kidney, heart, fetal tissues > lung, liver, skeletal muscle

More general terms

• flavoprotein
• oxidoreductase
• glycoprotein
• membrane protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=169714
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:169714
• OMIM: https://mirror.omim.org/entry/612860
• UniProt: http://www.uniprot.org/uniprot/Q6ZRP7.html