formimidoyltransferase-cyclodeaminase (formiminotransferase-cyclodeaminase, FTCD, LCHC1 [includes: glutamate formimidoyltransferase/glutamate formiminotransferase/glutamate formyltransferase & formimidoyltetrahydrofolate cyclodeaminase/formiminotetrahydrofolate cyclodeaminase])

Function

• folate-dependent enzyme
• displays both transferase & deaminase activity
• channels one-carbon units from formiminoglutamate to folate pool
• histidine degradation, 4th & steps
• may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Cofactor: pyridoxal phosphate

Structure

• homooctamer
• subunits are arranged as a tetramer of dimers, & form a planar ring-shaped structure
• polyglutamate binding sites

Compartment

cytoplasm

Alternative splicing

named isoforms=4

Pathology

• defects in FTCD are the cause of formiminoglutamicaciduria

Notes

• may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• enzyme

Database

• OMIM: https://mirror.omim.org/entry/229100
• OMIM: https://mirror.omim.org/entry/606806
• UniProt: http://www.uniprot.org/uniprot/O95954.html