progranulin
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Function
- role in wound healing
- skin injury stumulates progranulin mRNA production
- increases proliferation of fibroblasts in culture
- increases proliferation of endothelial cells in culture
- increases endothelial cell migration through collagen
- applied to wounds, progranulin increases numbers of:
- stimulates angiogenesis
- does not accelerate wound healing
Compartment
Alternative splicing
named isoforms=3
Expression
- expressed in myelogenous leukemic cell lines of promonocytic, promyelocytic, & proerythroid lineage
- expressed in fibroblasts
- strong expression in epithelial cell lines
- present in inflammatory cells & bone marrow
- highest levels in kidney
Pathology
- mutations in gene associated with frontotemporal dementia, ubiquitin-positive
- defects associated with neuronal ceroid lipofuscinosis 11
Laboratory
More general terms
References
- ↑ Journal Watch 23(6):51, 2003 He Z et al, Nat Med 9:225, 2003
- ↑ Baker M et al, Mutations in progranulin cause tau-negative frontotemporal dementa linked to chromosome 17. Nature 2006, 442:916 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16862116
Crus M et al, Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21 Nature 2006, 442:920 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16862115 - ↑ UniProt http://www.uniprot.org/uniprot/P28799.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/GRNID40757ch17q21.html
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2896
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2896
- OMIM: https://mirror.omim.org/entry/138945
- OMIM: https://mirror.omim.org/entry/607485
- OMIM: https://mirror.omim.org/entry/614706
- UniProt: http://www.uniprot.org/uniprot/P28799.html