Xin actin-binding repeat-containing protein 1 (cardiomyopathy-associated protein 1, XIRP1, CMYA1, XIN)

Function

• protects actin filaments from depolymerization
• interacts with CTNNB1 (putative)
• interacts with F-actin, FLNC & VASP

Structure

• Xin repeats bind F-actin
• belongs to the Xin family
• contains 15 Xin repeats

Compartment

• cell junction
• colocalizes with actin stress fibers

Alternative splicing

named isoforms=3

Expression

• isoform A, isoform B & isoform C are expressed in heart

Notes

'Xin' means 'heart' in chinese

More general terms

• cytoskeletal protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1659
• UniProt: http://www.uniprot.org/uniprot/Q702N8.html