formin-1 (limb deformity protein homolog, FMN1, FMN, LD)
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Function
- role in the formation of adherens junction & polymerization of linear actin cables (putative)
- interacts with alpha-catenin & may interact with tubulin (putative)
- phosphorylated on Ser & possibly Thr
Structure
- belongs to the formin homology family, Cappuccino subfamily
- contains 1 FH1 (formin homology 1) domain
- contains 1 FH2 (formin homology 2) domain
Compartment
- nucleus, cytoplasm cell junction, adherens junction
- peripheral membrane, cytoplasmic side (putative)
- localization to the adherens junctions is alpha-catenin- dependent
- also localizes to F-actin bundles originating from adherens junctions & to microtubules (putative)
Alternative splicing
named isoforms=3
Expression
expressed in fetal kidney & fetal lung