spindle & kinetochore-associated protein 2 (protein FAM33A, FAM33A, SKA2)

Function

• required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubulesleading to silencing of the spindle checkpoint
• role in maintenance of metaphase plate &/or spindle checkpoint silencing
• required for SKA1 localization

Structure

belongs to the SKA2 family

Compartment

• spindle, kinetochore
• localizes to both mitotic spindle & kinetochore-associated proteins

More general terms

• cytoskeletal protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WVK7.html