spindle & kinetochore-associated protein 1 (SKA1 C18orf24)

Function

• required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint
• role in maintenance of metaphase plate &/or spindle checkpoint silencing
• required for SKA2/FAM33A stability
• interacts directly & forms a complex with SKA2/FAM33A

Structure

belongs to the SKA1 family

Compartment

• spindle, kinetochore
• localizes to both mitotic spindle & kinetochore-associated proteins
• associates with kinetochores following microtubule attachment from prometaphase, through mid-anaphase & then vanishes in telophase

More general terms

• kinetochore protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96BD8.html