actin-related protein 5; hARP5; sarcoma antigen NY-SAR-16 (ACTR5, ARP5)

Function

• component of the chromatin remodeling INO80 complex, thus role in transcriptional regulation, DNA replication & DNA repair
  • role in DNA double-strand break repair
  • role in UV-damage excision repair
  • specifically part of a complex module associated with the helicase ATP-binding & helicase C-terminal domain of INO80
  • interacts with ACTR8
    • interaction is observed in interphase cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells
• interacts with DDB1

Structure

• belongs to the actin family, ARP5 subfamily

Compartment

• nucleus, cytoplasm
• predominantly nuclear but undergoes nuclear-cytoplasmic shuttling
• localized to interphase nuclei, but not nucleoli
• excluded from chromosomes as mitosis progresses

More general terms

• cytoskeletal protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79913
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79913
• UniProt: http://www.uniprot.org/uniprot/Q9H9F9.html