centrosomal protein of 170 kD (KARP-1-binding protein, KARP1-binding protein, CEP170, FAM68A, KAB, KIAA0470)

Function

• role in microtubule organization
• interacts with PLK1
• phosphorylated; probably by PLK1
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the CEP170 family
• contains 1 FHA domain

Compartment

• centrosome, centriole
• associated with the mature mother centriole
• associated with spindle microtubules during mitosis

Alternative splicing

named isoforms=3

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5SW79.html