zinc finger UBR1-type protein 1; retinoblastoma-associated factor of 600 kD; 600 kD retinoblastoma protein-associated factor; RBAF600; p600 (ZUBR1, KIAA0462, KIAA1307, RBAF600, UBR4)

Function

• together with clathrin, forms meshwork structures involved in membrane morphogenesis & cytoskeletal organization
• regulates integrin-mediated signaling
• role in activation of FAK in response to cell-matrix interactions (putative)
• interacts with RB1 & calmodulin
• interacts protein E7 from papilloma virus HPV-16, HPV-6B, HPV-11

Structure

• belongs to the ZUBR1 family
• contains 1 UBR-type zinc finger

Compartment

• membrane, cytoplasm, nucleus
• concentrates at the leading edge of membrane structures involved in actin motility

Alternative splicing

named isoforms=6

More general terms

• zinc finger protein
• cytoskeletal protein
• membrane protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5T4S7.html