macrophage erythroblast attacher (erythroblast macrophage protein, proliferation-inducing protein 5, lung cancer-related protein 10, MAEA, EMP)

Function

• role in erythroblast enucleation & in development of mature macrophages
• mediates attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages
• MAEA-mediated contact inhibits erythroid cells apoptosis
• role in erythroblastic island formation, functional unit of erythropoiesis
• associates with F-actin to regulate actin distribution in erythroblasts & macrophages
• role in nuclear architecture & cell division events (putative)

Structure

• contains 1 CTLH domain
• contains 1 LisH domain

Compartment

• nuclear matrix
• localized in speckled-like pattern
• localized with condensed chromatin at prophase
• detected in nuclear spindle poles at metaphase & in contractile ring during telophase & cytokinesis.

Alternative splicing

named isoforms=6

Expression

ubiquitous

More general terms

• cytoskeletal protein

Database

• OMIM: https://mirror.omim.org/entry/606801
• UniProt: http://www.uniprot.org/uniprot/Q7L5Y9.html