coactosin-like protein (COTL1 CLP)

Function

• binds to F-actin (Ca+2-independent)
• no direct effect on actin depolymerization
• interacts with 5-lipoxygenase (Ca+2-independent)

Structure

• belongs to the actin-binding proteins ADF family, coactosin subfamily
• contains 1 ADF-H domain

Expression

• widely expressed
• highest levels in placenta, lung, kidney, peripheral blood leukocytes > brain, liver, pancreas

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606748
• UniProt: http://www.uniprot.org/uniprot/Q14019.html