intersectin-2 (SH3 domain-containing protein 1B, SH3P18, SH3P18-like WASP-associated protein, ITSN2, KIAA1256, SH3D1B, SWAP)

Function

• adapter protein
• indirect link between endocytic membrane traffic & actin assembly (putative)
• regulates formation of clathrin-coated vesicles
• component of complex that may contain multimers of ITSN1, ITSN2, EPS15
• overexpression inhibits transferrin uptake & blocks clathrin-mediated endocytosis

Compartment

cytoplasm

Alternative splicing

named isoforms=4

Expression

• ubiquitous
• isoform 1 is primarily expressed in adult heart & liver

More general terms

• phosphoprotein
• cytoskeletal protein
• Ca+2 binding protein

Database

• OMIM: https://mirror.omim.org/entry/604464
• UniProt: http://www.uniprot.org/uniprot/Q9NZM3.html