protein Niban; cell growth-inhibiting gene 39 protein; protein FAM129A (FAM129A, C1orf24, NIBAN, GIG39)

Function

• regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 & RPS6KB1
• may be involved in the endoplasmic reticulum stress response (putative)

Structure

• belongs to the Niban family

Compartment

cytoplasm

Expression

• strongly expressed in heart, skeletal muscle, pancreas, white blood cells & prostate
• lesser expression in colon & spleen
• not expressed in normal thyroid tissue or normal kidney

Pathology

• expressed in renal carcinoma cells
• expressed thyroid tumors
  • papillary thyroid carcinoma
  • oxyphilic thyroid tumors

More general terms

• cytoskeletal protein
• phosphoprotein

Additional terms

• renal cell carcinoma (hypernephroma, Grawitz tumor)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=116496
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:116496
• UniProt: http://www.uniprot.org/uniprot/Q9BZQ8.html