fascin; singed-like protein; 55 kD actin-bundling protein; p55 (FSCN1, FAN1, HSN, SNL)

Function

• organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio
• probably involved in the assembly of actin filament bundles present in microspikes, membrane ruffles, & stress fibers
• phosphorylation on Ser-39 inhibits the actin-binding ability of fascin
• associates with beta-catenin

Structure

belongs to the fascin family

Expression

ubiquitous

Pathology

• marks & mediates breast cancer metastasis to the lungs

More general terms

• cytoskeletal protein
• phosphoprotein

Additional terms

• Fascin-2; retinal fascin (FSCN2)
• Fascin-3; testis fascin (FSCN3)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6624
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6624
• OMIM: https://mirror.omim.org/entry/602689
• UniProt: http://www.uniprot.org/uniprot/Q16658.html