tumor suppressor candidate 2; PDGFA-associated protein 2; Fus-1 protein; fusion 1 protein (TUSC2, FUS1, LGCC, PDAP2)

Function

• tumor suppressor (putative)
  • myristoylation is required for tumor suppressor activity
• inhibits colony formation, causing G1 arrest & ultimately induces apoptosis in homozygous 3p21.3 120-kb region- deficient cells

Structure

belongs to the TUSC2 family

Expression

• expression in heart, lung, skeletal muscle, kidney, pancreas > brain, liver > placenta

More general terms

• anti-oncoprotein (tumor suppressor protein)
• myristoylated protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11334
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11334
• OMIM: https://mirror.omim.org/entry/607052
• UniProt: http://www.uniprot.org/uniprot/O75896.html