K+ channel regulatory protein KCNRG; K+ channel regulator (KCNRG, CLLD4)

Function

• inhibits K+ fluxes in cells
• may regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes
• interacts with KCNA1 (via cytoplasmic N-terminal domain)
• interacts with KCNA4
• tumor suppressor (putative)

Structure

contains 1 BTB/POZ domain

Compartment

endoplasmic reticulum

Alternative splicing

named isoforms=2

Expression

ubiquitous in normal tissues

Pathology

• expressed in some tumor tissues
• tumor suppressor (putative)
  • B-cell chronic lymphocytic leukemia
  • prostate cancer
• chromosomal deletion 13q14 involving KCNRG associated with B-cell chronic lymphocytic leukemia

More general terms

• anti-oncoprotein (tumor suppressor protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=283518
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:283518
• OMIM: https://mirror.omim.org/entry/607947
• UniProt: http://www.uniprot.org/uniprot/Q8N5I3.html